Example Concept: A multi-region VPC architecture typically involves creating VPCs in each region with peering connections or transit gateways to enable inter-region communication. Each VPC should have subnets distributed across multiple availability zones to enhance fault tolerance. Implementing a global load balancer can distribute traffic across regions, while using services like AWS Global Accelerator can improve latency and availability. Security groups and network ACLs should be consistently configured across regions to maintain security posture.